Leslie Mann Details Judd Apatow’s Ozempic Weight Gain, Not Weight Loss

The Queer Eye star explained in October 2025 that they started using a GLP-1 after a health scare in 2023.

“I decided then that after the medical issue, I was going to get a colonoscopy,” Jonathan said in a TikTok video, “and if I didn’t have anything severely wrong with me, I was going to go on a GLP-1, because I just didn’t feel good.”

They added, “As I’ve lost weight and I got into [Pilates classes at] Solidcore, my body has never looked like this,” Jonathan said. “My body’s never in my whole life—I’ve always wanted to have an ab. I’ve never had abs. And I feel really good, so I’m taking my shirt off a lot.”

Despite losing 70 pounds with the help of the drug, Jonathan re-emphasized their stance on body positivity.

“I’m all about body neutrality,” they continued. “The way that you look does not define your worth, doesn’t define your lovableness. You are worth love and worth celebration no matter what your body looks like.”